N-(3-Chlorophenyl)-2-[[(3,4-dimethoxyphenyl)methyl]amino]acetamide → N-(3-chlorophenyl)-N'-[(3,4-dimethoxyphenyl)methyl]-1,2-ethanediamine

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=O)[CH2:10][NH:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][CH2:9][CH2:10][NH:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=2)[CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 14998797N-(3-Chlorophenyl)-2-[[(3,4-dimethoxyphenyl)methyl]amino]acetamide

HCID 21226445Aluminium lithium hydride

生成物 1

HCID 14998759N-(3-chlorophenyl)-N'-[(3,4-dimethoxyphenyl)methyl]-1,2-ethanediamine

実験手順

In a manner similar to Preparation 2, react N-(3-chlorophenyl)-2-[[(3,4-dimethoxyphenyl)methyl]amino]acetamide (13.6 g, 40.1 mmol) with lithium aluminum hydride (3.1 g, 81 mmol) to obtain the title compound.

後処理

customIn a manner similar to Preparation 2

出典と根拠

ORDレコード: ord-b532a3de67f84d28b74cb7a6cf6f18f2
出典データセット: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05223623

反応ノート

読み込み中…

参加物