Water → HCID 13579285、化合物

HRID 1589094ノート

反応式

HRID 1589094 の反応式
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:4]=[C:5]([CH:9]([C:12]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:13])[C:10]#[N:11])[CH:6]=[CH:7][CH:8]=1.BrBr.[OH2:25]>C(O)(=O)C>[C:15]1([CH:14]2[C:12](=[O:13])[C:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:21])([F:22])[F:1])[CH:4]=3)=[C:10]([NH2:11])[O:25]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 106559Benzenebutanenitrile, beta-oxo-alpha-(3-(trifluoromethyl)phenyl)-

生成物 1

HCID 13579285HCID 13579285、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

In this example a solution containing 21.8 g of (3-trifluoromethylphenyl)-benzylcarbonyl-acetonitrile, dissolved in 60 ml of acetic acid was treated dropwise with a solution of 12.65 g of bromine in 20 ml of glacial acetic acid. The reaction mixture was stirred for about 16 hours at room temperature. The reaction mixture was poured into 250 ml of water and the resulting mixture was extracted three times with ethyl ether. The organic extracts were washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate and concentrated in vacuo to yield 8.4 g of white solid which was dried affording 7.0 g of the title compound.

後処理

  1. extractionthe resulting mixture was extracted three times with ethyl ether
  2. washThe organic extracts were washed with saturated aqueous sodium bicarbonate
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e8e80ca9ab5f4b218c27e82b6a5df8e0
出典データセット
uspto-grants-1986_02
特許番号
US04568376

反応ノート

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