Hydrochloric Acid → Aditeren

HRID 1589247

反応式

HRID 1589247 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9]O)=[CH:4][N:3]=1.NC1N=C(N)C(C#N)=CN=1.[CH3:21][O:22][C:23]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[C:24]=1[NH2:25].Cl>C(O)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:28]2[CH:27]=[C:26]([O:30][CH3:31])[C:24]([NH2:25])=[C:23]([O:22][CH3:21])[CH:29]=2)=[CH:4][N:3]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 95940Benzenamine, 2,6-dimethoxy-HCID 2821152,4-Diaminopyrimidine-5-carbonitrileHCID 2958782,4-Diamino-5-pyrimidinemethanol

生成物 1

HCID 176875Aditeren収率 86.3%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 2,4-diamino-5-hydroxymethylpyrimidine (4.30 g, 30.0 mmol), prepared from 2,4-diamino-5-cyanopyrimidine as described in U.K. Pat. No. 1 413 472, 2,6-dimethoxyaniline (5.05 g, 33.0 mmol), acetic acid (60 mL), and concentrated hydrochloric acid (4.2 mL) was refluxed for 41/2 hours, cooled, and filtered to give the hydrochloride salt of the title compound (7.13 g, 76.2%). The salt was dissolved in water and the solution made basic with concentrated ammonium hydroxide. The resulting precipitate was filtered, washed with water, and dried to give the title compound (5.18 g, 62.7%).

後処理

  1. temperaturecooled
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-ee60d8fc91e14d57a05c49a77102e768
出典データセット
uspto-grants-1986_02
特許番号
US04568744

関連ノート

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