2-Bromopropane → 4-((4-Isopropoxyphenyl)sulfonyl)phenol

HRID 1589285ノート

反応式

HRID 1589285 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH:18](Br)([CH3:20])[CH3:19].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:19][CH:18]([O:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:6][CH:7]=1)[CH3:20]

参加物

5

反応物 3

HCID 63582-BromopropaneHCID 6626Bisphenol SHCID 11430Potassium Carbonate

生成物 1

HCID 99041414-((4-Isopropoxyphenyl)sulfonyl)phenol収率 44.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
120 °C

実験手順

30.3 g of bis(p-hydroxyphenyl)sulfone, 18.5 g of isopropylbromide, and 22.2 g of potassium carbonate as acid-binding agent were added to 200 ml of dimethylformamide, then stirred for 4 hours at about 120° C. and dimethylformamide was distilled off under reduced pressure. When this was accomplished, chloroform was added to the residue to extract crude 4-hydroxy-4'-isopropoxydiphenylsulfone. Then this crude compound was refined by using a silica gel column chromatography and 15.7 g of 4-hydroxy-4'-isopropoxydiphenylsulfone was obtained in white microfine crystals with a melting point of 129.0°~131.0° C.

後処理

  1. distillationdimethylformamide was distilled off under reduced pressure
  2. additionchloroform was added to the residue
  3. extractionto extract crude 4-hydroxy-4'-isopropoxydiphenylsulfone

出典と根拠

ORDレコード
ord-7946325dcb10422f8e58880afab3ab16
出典データセット
uspto-grants-1986_02
特許番号
US04568766

反応ノート

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