Ammonia → HCID 70455630、化合物

HRID 1589297ノート

反応式

HRID 1589297 の反応式
Cl.C[O:3][C:4]1[C:9]([NH2:10])=[C:8]([NH2:11])[CH:7]=[CH:6][N:5]=1.[CH3:12][O:13][C:14]1[CH:22]=[C:21]([S:23][CH3:24])[CH:20]=[CH:19][C:15]=1[C:16](Cl)=O.N>O>[CH3:12][O:13][C:14]1[CH:22]=[C:21]([S:23][CH3:24])[CH:20]=[CH:19][C:15]=1[C:16]1[N:10]=[C:9]2[C:4](=[O:3])[NH:5][CH2:6][CH:7]=[C:8]2[N:11]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 27595912-Methoxy-4-(methylthio)benzoyl chlorideHCID 202482542-Methoxy-3,4-diamino-pyridine hydrochloride

生成物 1

HCID 70455630HCID 70455630、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.88 g of 2-methoxy-3,4-diamino-pyridine hydrochloride and 1.08 g of 2-methoxy-4-methylmercapto-benzoyl chloride were intimately mixed, and the mixture was stirred into warm polyphosphoric acid at 120° C. The mixture was kept at this temperature for an hour and was then poured into water, the aqueous mixture was made alkaline with ammonia, and the precipitate thus obtained was purified on a silica gel column (eluant: methylene chloride/methanol=100:10).

後処理

  1. waitThe mixture was kept at this temperature for an hour
  2. customthe precipitate thus obtained
  3. customwas purified on a silica gel column (eluant: methylene chloride/methanol=100:10)

出典と根拠

ORDレコード
ord-8eb90bdb6e014f0b9d71834aa967875a
出典データセット
uspto-grants-1986_02
特許番号
US04568680

反応ノート

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