Fumarate → bromomesaconic acid

HRID 1589333ノート

反応式

HRID 1589333 の反応式
[Br:1][CH2:2]/[C:3](=[CH:7]/[C:8]([OH:10])=[O:9])/[C:4]([OH:6])=[O:5].C([O-])(=O)/C=C/C([O-])=O.BrCC1C(OC(=O)C=1)=O>>[Br:1][CH2:2]/[C:3](=[CH:7]\[C:8]([OH:10])=[O:9])/[C:4]([OH:6])=[O:5]

参加物

4

反応物 3

HCID 5460307FumarateHCID 109870762,5-Furandione, 3-(bromomethyl)-HCID 86740308HCID 86740308、化合物2 回

生成物 1

HCID 6449799bromomesaconic acid

実験手順

Steps are taken to avoid isomerization of 2-(bromomethyl)-maleic acid (3) to the corresponding fumarate analog by hydrolyzing the anhydride (2) in a dilute aqueous solution and neutralizing the diacid (3) immediately after complete hydrolysis. Any bromomethyl fumaric acid derivative formed is removed in purifying compound (4) as described in more detail below.

後処理

  1. customimmediately after complete hydrolysis

出典と根拠

ORDレコード
ord-175c0a18416848a2975bcd98424f1b90
出典データセット
uspto-grants-1986_02
特許番号
US04569789

反応ノート

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