Isopropyl isocyanate → 1-N-i-Propylcarbamoyloxindole

HRID 1589383ノート

反応式

HRID 1589383 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH:11]([N:14]=[C:15]=[O:16])([CH3:13])[CH3:12]>C1(C)C=CC=CC=1>[CH:11]([NH:14][C:15]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10])=[O:16])([CH3:13])[CH3:12]

参加物

4

反応物 2

HCID 61277Isopropyl isocyanateHCID 321710Oxindole

生成物 1

HCID 135656731-N-i-Propylcarbamoyloxindole収率 85.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a stirred suspension of 5.0 g (37.6 mmole) of 2-oxindole in 50 ml of toluene was added 8.0 g (94.0 mmole) of isopropyl isocyanate, and the mixture was heated under reflux for 6 hours. The reaction mixture was allowed to cool and then it was stirred at room temperature overnight. The solvent was removed by evaporation in vacuo, and the residue was dissolved in hot cyclohexane. The solution was allowed to cool and the solid was collected by filtration, giving 7.0 g of the title compound, mp 84°-85.5° C., as pink crystals.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 6 hours
  3. temperatureto cool
  4. customThe solvent was removed by evaporation in vacuo
  5. dissolutionthe residue was dissolved in hot cyclohexane
  6. temperatureto cool
  7. filtrationthe solid was collected by filtration

出典と根拠

ORDレコード
ord-6a442c4003c44daeb58d6b9920334144
出典データセット
uspto-grants-1986_02
特許番号
US04569942

反応ノート

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