関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Magnesium orthosilicate | HCID 66225 | — |
| 反応物 | 3-Chloro-6-[3-(trifluoromethyl)phenyl]pyridazine | HCID 12449552 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Methyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine | HCID 13565362 | 28.8% |
反応手順
A mixture of 5.18 g of 3-chloro-6-[3-(trifluoromethyl)phenyl]pyridazine and 4.60 g of aminoacetoneethyleneketal was heated at 150° C. under argon for 4 hours. The cooled mixture was dissolved in dichloromethane and the solution passed through a short pad of hydrous magnesium silicate. The filtrate was concentrated, diluted with hexane and chilled to give 0.8 g of crystals, mp 98°-100° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04569934 |
|---|
| 出典データセット | uspto-grants-1986_02 |
|---|
| ORD ID | ord-2e9c1a9597994fd2a9b681da0e39e9b5 |
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| 出典メモ | uspto-grants-1986_02 |
|---|
