Ammonia → 3-Amino-6-(3-trifluoromethylphenyl)pyridazine

HRID 1589466ノート

反応式

HRID 1589466 の反応式
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)=[CH:6][CH:7]=1.[NH3:18]>>[NH2:18][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 222Ammonia2 回HCID 124495523-Chloro-6-[3-(trifluoromethyl)phenyl]pyridazine

生成物 1

HCID 135653673-Amino-6-(3-trifluoromethylphenyl)pyridazine

反応条件

温度
200 °C

実験手順

A 12.5 g sample of 3-chloro-6-[3-(trifluoromethyl)phenyl]pyridazine was placed in a steel cylinder with liquid ammonia and the sealed cylinder (bomb) was heated at 200° C. The chilled cylinder was opened and the ammonia allowed to evaporate. The solid residue was heated and stirred with chloroform, then filtered. The filtrate was concentrated and the residue recrystallized, first from chloroform-hexane, then twice from chloroform to give 1.8 g of 3-amino-6-[3-(trifluoromethyl)phenyl]pyridazine as white crystals, mp 143°-145° C.

後処理

  1. customto evaporate
  2. temperatureThe solid residue was heated
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated
  5. customthe residue recrystallized, first from chloroform-hexane

出典と根拠

ORDレコード
ord-249344310eed46bab2a8f1c73e2d6122
出典データセット
uspto-grants-1986_02
特許番号
US04569934

反応ノート

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