Ethanol → 3-Amino-6-(3-trifluoromethylphenyl)pyridazine

HRID 1589467ノート

反応式

HRID 1589467 の反応式
[NH:1]([C:3]1[N:4]=[N:5][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)=[CH:7][CH:8]=1)N.C(O)C.[H][H]>[Ni].O>[NH2:1][C:3]1[N:4]=[N:5][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:17])([F:16])[F:18])[CH:10]=2)=[CH:7][CH:8]=1

参加物

6

反応物 3

HCID 702EthanolHCID 127268553-Hydrazinyl-6-[3-(trifluoromethyl)phenyl]pyridazineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 135653673-Amino-6-(3-trifluoromethylphenyl)pyridazine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 962Water溶媒

実験手順

Alternatively, 5.0 g of 3-hydrazino-6-[3-(trifluoromethyl)phenyl]pyridazine, 100 ml of ethanol, 10 ml of water and Raney nickel catalyst was shaken with hydrogen under 40 pounds of pressure in a Parr apparatus for 18 hours. The mixture was cooled and filtered and the filtrate concentrated to a gummy soid which was crystallized from dichloromethane-hexane to give 3-amino-6-[3-(trifluoromethyl)phenyl]pyridazine as off-white crystals, mp 138°-139° C.

後処理

  1. temperatureThe mixture was cooled
  2. filtrationfiltered
  3. concentrationthe filtrate concentrated to a gummy soid which
  4. customwas crystallized from dichloromethane-hexane

出典と根拠

ORDレコード
ord-43f6a12e4a144161ad3d5225df8e846f
出典データセット
uspto-grants-1986_02
特許番号
US04569934

反応ノート

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