Bromoacetone → 2-Methyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine hydrobromide

HRID 1589468ノート

反応式

HRID 1589468 の反応式
[NH2:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)=[CH:6][CH:7]=1.[Br:18][CH2:19][C:20](=O)[CH3:21]>C(O)C>[BrH:18].[CH3:21][C:20]1[N:1]=[C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:17])[F:16])[CH:9]=3)=[N:4][N:3]2[CH:19]=1

参加物

4

反応物 2

HCID 11715BromoacetoneHCID 135653673-Amino-6-(3-trifluoromethylphenyl)pyridazine

生成物 1

HCID 135653662-Methyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine hydrobromide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A 1.5 g sample of 3-amino-6-[3-(trifluoromethyl)phenyl]pyridazine, 1.23 g of bromoacetone and 50 ml of ethanol was refluxed for 18 hours. The volatiles were removed in vacuo and the residue dissolved in dichloromethane. The solution was treated with activated carbon, filtered, and concentrated. The residue was crystallized from dichloromethane-hexane to give 1.0 g of the desired product as cream colored crystals, mp 219°-221° C.

後処理

  1. customThe volatiles were removed in vacuo
  2. dissolutionthe residue dissolved in dichloromethane
  3. additionThe solution was treated with activated carbon
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe residue was crystallized from dichloromethane-hexane

出典と根拠

ORDレコード
ord-ebc16b882c6f455cae49408f6a73502d
出典データセット
uspto-grants-1986_02
特許番号
US04569934

反応ノート

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