3-Methyl-1-naphthyl acetate → 1-Naphthol, 3-methyl-

HRID 1589730

反応式

HRID 1589730 の反応式
C([O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[C:7]([CH3:15])[CH:6]=1)(=O)C>[OH-].[K+]>[CH3:15][C:7]1[CH:6]=[C:5]([OH:4])[C:14]2[C:9]([CH:8]=1)=[CH:10][CH:11]=[CH:12][CH:13]=2

参加物

3

反応物 1

HCID 137648093-Methyl-1-naphthyl acetate

生成物 1

HCID 261351-Naphthol, 3-methyl-収率 27.7%

試薬・触媒・溶媒 1

HCID 14797Potassium Hydroxide溶媒

実験手順

Crude 1-acetoxy-3-methylnaphthalene (84 g, 0.42 mole) was boiled with 10% ethanolic potassium hydroxide (300 cm3) for 3 hours. Ethanol was distilled off and the residue dissolved in water and extracted with toluene to remove neutral products. The aqueous alkaline solution was carefully acidified with dilute hydrochloric acid and the liberated 3-methyl-l-naphthol extracted with ether. The ether extract was washed with water, dried and filtered. Ether solvent was removed leaving 3-methyl-l-naphthol (18.4 g) as clear colorless crystals.

後処理

  1. distillationEthanol was distilled off
  2. dissolutionthe residue dissolved in water
  3. extractionextracted with toluene
  4. customto remove neutral products
  5. extractionthe liberated 3-methyl-l-naphthol extracted with ether
  6. extractionThe ether extract
  7. washwas washed with water
  8. customdried
  9. filtrationfiltered
  10. customEther solvent was removed

出典と根拠

ORDレコード
ord-12990e0e8b8d420b9995ac40ed251615
出典データセット
uspto-grants-1993_04
特許番号
US05200116

関連ノート

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