Water → HCID 178447875、化合物

HRID 1589742ノート

反応式

HRID 1589742 の反応式
[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10]2[CH:18]=[CH:17][C:13]([CH2:14][C:15]#N)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)[CH2:2][CH3:3].[OH2:19].[OH-:20].[K+]>CO>[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10]2[CH:18]=[CH:17][C:13]([CH2:14][C:15]([OH:20])=[O:19])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)[CH2:2][CH3:3]

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 178447873HCID 178447873、化合物

生成物 1

HCID 178447875HCID 178447875、化合物収率 97.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

106 g (0.44 mol) of 4-(trans-4'-propylcyclohexyl) benzyl cyanide, 40 g of water, 145 g (2.2 mol) of KOH and 440 cm3 of methanol were refluxed for 10 hours using a mantle heater. The ethanol was distilled off under reduced pressure. The residue was dissolved in 300 cm3 of water and poured into 300 cm3 of concentrated hydrochloric acid and 300 g of ice. The crystals deposited were filtered out and washed with cold water. The crystals were recrystallized from methanol to yield 112 g (0.43 mol) of 4-(trans-4'-propylcyclohexyl)phenyl acetic acid.

後処理

  1. distillationThe ethanol was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved in 300 cm3 of water
  3. additionpoured into 300 cm3 of concentrated hydrochloric acid and 300 g of ice
  4. filtrationThe crystals deposited were filtered out
  5. washwashed with cold water
  6. customThe crystals were recrystallized from methanol

出典と根拠

ORDレコード
ord-af198656fdec4b6d8e75434dfa446362
出典データセット
uspto-grants-1993_04
特許番号
US05200110

反応ノート

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