Ammonia → 4-Bromo-3,5-difluorobenzimidamide Hydrochloride
反応式
[NH3:1].[ClH:2].[Br:3][C:4]1[C:12]([F:13])=[CH:11][C:7]([C:8](=[NH:10])O)=[CH:6][C:5]=1[F:14]>C(O)C>[ClH:2].[Br:3][C:4]1[C:12]([F:13])=[CH:11][C:7]([C:8]([NH2:1])=[NH:10])=[CH:6][C:5]=1[F:14]参加物
4
実験手順
450 cm3 of anhydrous ethanol saturated with dried gaseous ammonia was added to 4-bromo-3,5-difluorobenzimidate hydrogen chloride and stirred overnight at room temperature. About one-half of the volume of the solvent was distilled off and the residue was recrystallized to yield 90 g (0.36 mol) of 4-bromo-3,5-difluorobenzamidine hydrogen chloride.
後処理
- distillationAbout one-half of the volume of the solvent was distilled off
- customthe residue was recrystallized
出典と根拠
- ORDレコード
- ord-f6eec6f26b3e4653a55336994f5e4806
- 出典データセット
- uspto-grants-1993_04
- 特許番号
- US05200110
反応ノート
読み込み中…