2-amino-3,6-dichloroPhenol → 2-Chloromethyl-4,7-dichlorobenzoxazole
反応式
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[OH:10].[ClH:11].ClN=CC(O[CH2:18][CH3:19])=O>C(Cl)Cl>[Cl:11][CH2:18][C:19]1[O:10][C:3]2[C:4]([Cl:9])=[CH:5][CH:6]=[C:7]([Cl:8])[C:2]=2[N:1]=1参加物
4
実験手順
To a solution of 2-amino-3,6-dichlorophenol (23. g, 134 mmol) in methylene chloride (270 mL), solid ethyl chloroiminoacetate hydrogen chloride (31.9 g, 202 mmol) was added. The resultant slurry was stirred at room temperature overnight, then filtered through a plug of Celite, and concentrated under reduced pressure (15 torr). The solid residue was subjected to column chromatography on silica gel (elution with chloroform). Collection and concentration of appropriate fractions yielded 26.6 g (86%) of 2-chloromethyl-4,7-dichlorobenzoxazole.
後処理
- filtrationfiltered through a plug of Celite
- concentrationconcentrated under reduced pressure (15 torr)
- customCollection and concentration of appropriate fractions
出典と根拠
- ORDレコード
- ord-800e31f3f2fb4da5a0114594802d451a
- 出典データセット
- uspto-grants-1993_04
- 特許番号
- US05200329
反応ノート
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