化工社化工社 化学情報印刷レポート · 研究参考用
Cortisol → Butanoic acid, 2-ethyl-3-oxo-, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cortisol | HCID 5754 | — |
| 反応物 | Prednisolone | HCID 5755 | — |
| 反応物 | Perchloric Acid | HCID 24247 | — |
| 反応物 | 11beta,17,20beta,21-Tetrahydroxypregna-1,4-dien-3-one 21-Acetate | HCID 13962388 | — |
| 生成物 | Butanoic acid, 2-ethyl-3-oxo-, methyl ester | HCID 103534 | — |
反応手順
Hydrocortisone or prednisolone with 20-hydroxy and 21-acetoxy groups are known, e.g., (I) (20R)-21-acetoxy-11β, 17,20-trihydroxy-3-oxo-1,4-pregnadiene; and (I) is reacted with an alkyl acetylalkanoate in the presence of perchloric acid to produce the corresponding 17,20-carboxycyclic acetal pregnane derivatives, e.g., when methyl acetylbutyrate is used the product is (II) (20R)-21-acetoxy-11β-hydroxy-3-oxo-17,20-(methyl,methoxycarbonyl-n-propyl)methylenedioxy-1,4-pregnadiene;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05200518 |
| 出典データセット | uspto-grants-1993_04 |
| ORD ID | ord-8ef4d1660fef44e1bc2033b1081f7dac |
| 出典メモ | uspto-grants-1993_04 |