Imidazo(1,2-b)pyridazine, 6-chloro- → Sodium 2-[(imidazo[1,2-b]pyridazin-6-yl)thio]ethanesulfonate
反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[SH:11][CH2:12][CH2:13][S:14]([O-:17])(=[O:16])=[O:15].[Na+:18].CO.[Na]>CO>[N:10]1[CH:9]=[CH:8][N:6]2[C:5]=1[CH:4]=[CH:3][C:2]([S:11][CH2:12][CH2:13][S:14]([O-:17])(=[O:16])=[O:15])=[N:7]2.[Na+:18]参加物
5
実験手順
To a solution of 1.35 g of 6-chloroimidazo[1,2-b]pyridazine in 30 ml of methanol were added 1.45 g of sodium 2-mercaptoethanesulfonate and 1.80 ml of 28 W/W % sodium-methanol solution, followed by refluxing for 5 hours. The precipitated crystals were collected by filtration and washed with methanol to obtain 1.98 g of sodium 2-[(imidazo[1,2-b]pyridazin-6-yl)thio]ethanesulfonate.
後処理
- temperatureby refluxing for 5 hours
- filtrationThe precipitated crystals were collected by filtration
- washwashed with methanol
出典と根拠
- ORDレコード
- ord-8e1ca44ec6424f899115e44a0025e9d4
- 出典データセット
- uspto-grants-1993_04
- 特許番号
- US05202324
反応ノート
読み込み中…