HCID 19100959、化合物 → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 1590141ノート

反応式

HRID 1590141 の反応式
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

参加物

3

反応物 1

HCID 19100959HCID 19100959、化合物

生成物 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate together with 30 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the concentrate is taken up in 30 ml of water, this mixture is rendered alkaline using potassium carbonate and extracted five times using 50 ml portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

後処理

  1. concentrationThe mixture is concentrated
  2. extractionextracted five times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationdistilled

出典と根拠

ORDレコード
ord-d240346758624e2d8ec55f8e8f4a3a77
出典データセット
uspto-grants-1993_04
特許番号
US05202337

反応ノート

読み込み中…