Potassium Carbonate → Decahydropyrrolo[3,4-b]pyrrolizine

HRID 1590142ノート

反応式

HRID 1590142 の反応式
[N:1]12[CH2:11][CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][N:4](C(OCC)=O)[CH2:5]1.C(=O)([O-])[O-].[K+].[K+]>Cl>[N:1]12[CH2:11][CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][NH:4][CH2:5]1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 53870311Ethyl 1,4-diazatricyclo[6.3.0.02,6]undecane-4-carboxylate

生成物 1

HCID 16227934Decahydropyrrolo[3,4-b]pyrrolizine

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

9 g (40 mmol) of ethyl 1,4-diazatricyclo[6.3.0.02,6 ]undecane-4-carboxylate together with 50 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

後処理

  1. extractionextracted ten times
  2. dry with materialthe extracts are dried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-79bb493c45a4460e9b73cac24d0f5895
出典データセット
uspto-grants-1993_04
特許番号
US05202337

反応ノート

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