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Potassium Carbonate → Ethyl (Z)-alpha-((2-(tert-butoxy)-1,1-dimethyl-2-oxoethoxy)imino)-2-(tritylamino)thiazol-4-acetate

HRID 1590270
ノート
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反応式

HRID 1590270 の反応式
[OH:1]/[N:2]=[C:3](/[C:9]1[N:10]=[C:11]([NH:14][C:15]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[S:12][CH:13]=1)\[C:4]([O:6][CH2:7][CH3:8])=[O:5].C(=O)([O-])[O-].[K+].[K+].[C:40]([O:44][C:45](=[O:50])[C:46](Br)([CH3:48])[CH3:47])([CH3:43])([CH3:42])[CH3:41]>CS(C)=O>[C:40]([O:44][C:45]([C:46]([O:1]/[N:2]=[C:3](/[C:9]1[N:10]=[C:11]([NH:14][C:15]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[S:12][CH:13]=1)\[C:4]([O:6][CH2:7][CH3:8])=[O:5])([CH3:48])[CH3:47])=[O:50])([CH3:43])([CH3:42])[CH3:41]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 90290tert-Butyl 2-bromo-2-methylpropionateHCID 6410761(Z)-Ethyl 2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate

生成物 1

HCID 12822365Ethyl (Z)-alpha-((2-(tert-butoxy)-1,1-dimethyl-2-oxoethoxy)imino)-2-(tritylamino)thiazol-4-acetate収率 74.8%

試薬・触媒・溶媒 1

HCID 679
Dimethyl Sulfoxide
溶媒

実験手順

To ethyl (Z)-2-(hydroxyimino)-2-[2-(triphenylmethyl)aminothiazol-4-yl]acetate (46 g) were added potassium carbonate (27.6 g), tert-butyl-2-bromo-2-methylpropionate(24.1 g) and dimethylsulfoxide (300 ml), and then the solution was stirred for 6 hours at room temperature. Afterwards distilled water (100 ml) was added therein, the solution was stirred again for an hour. The precipitates were filtered, washed with distilled water(500 ml), and dried under reduced pressure to give the above-indicated compound(45.1 g) as a white solid.

後処理

  1. distillationAfterwards distilled water (100 ml)
  2. additionwas added
  3. stirringthe solution was stirred again for an hour
  4. filtrationThe precipitates were filtered
  5. washwashed with distilled water(500 ml)
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-23b749df836d4d2bb0d67a995540b276
出典データセット
uspto-grants-1993_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05202315

反応ノート

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