2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine → 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)benzonitrile

HRID 1590616ノート

反応式

HRID 1590616 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][C:14](Br)=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.[C:18]([Cu])#[N:19].C(N)CN.O>CN(C=O)C>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([C:18]#[N:19])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1

参加物

5

反応物 3

HCID 8378932-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridineHCID 12200817Ethylenediamine monohydrateHCID 178418546HCID 178418546、化合物

生成物 1

HCID 7359124-(6-Methylimidazo[1,2-a]pyridin-2-yl)benzonitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

6-Methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine (6.0 g) was mixed with 3.0 g of CuCN and 50 ml DMF. The mixture was refluxed for 24 hrs. The hot solution was then poured into a (1:4) ethylenediamine-water mixture (200 ml). Using chloroform, the compound was extracted. The chloroform layer was washed with water, dried and evaporated. The residue was crystallized and recrystallized from ethanol; yield; 3.4 g (69%); mp 225°-226° C.

後処理

  1. temperatureThe mixture was refluxed for 24 hrs
  2. extractionUsing chloroform, the compound was extracted
  3. washThe chloroform layer was washed with water
  4. customdried
  5. customevaporated
  6. customThe residue was crystallized
  7. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-f3a59b841d974501bf7bbc78456eb120
出典データセット
uspto-grants-1993_04
特許番号
US05204352

反応ノート

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