化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → (RS)-Clopidogrel
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Methyl [2-(2-thienyl)ethylamino](2-chlorophenyl)acetate | HCID 10223136 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (RS)-Clopidogrel | HCID 2806 | — |
反応手順
35 g of the hydrochloride of racemic methyl alpha-(2-thienylethylamino)(2-chlorophenyl)acetate are suspended in 150 ml of a 30% (w/w) aqueous solution of formaldehyde. The mixture is kept at 50° C. for 2 hours and then poured, at about 20° C., into 200 ml of methylene chloride. The organic phase is concentrated and the residual oil is dissolved in 120 ml of isopropyl ether in which the hydrochloride is prepared as before; 29.5 g are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05204469 |
| 出典データセット | uspto-grants-1993_04 |
| ORD ID | ord-f5c9992b4803468f97c3f790d71a0507 |
| 出典メモ | uspto-grants-1993_04 |