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Benzyl lactate → 2-(4-Octyloxy-2-fluorophenyl)-5-(1-cyanoethoxy)-pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl lactate | HCID 98054 | — |
| 反応物 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 反応物 | 2-(4-Octyloxy-2-fluorophenyl)-5-hydroxypyridine | HCID 22717460 | — |
| 生成物 | 2-(4-Octyloxy-2-fluorophenyl)-5-(1-cyanoethoxy)-pyridine | HCID 19768414 | — |
反応手順
Optically active benzyl lactate is etherified by means of diethyl azodicarboxylate (DEAD)/triphenylphosphine with 2-(4-octyloxy-2-fluorophenyl)-5-hydroxypyridine (prepared in accordance with Example 1) and the benzyl group is then split off hydrogenolytically. The acid so obtained is converted as usual into the nitrile (oxalyl chloride, ammonia, thionyl chloride). Optically active 2-(4-octyloxy-2-fluorophenyl)-5-(1-cyanoethoxy)-pyridine is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05204476 |
| 出典データセット | uspto-grants-1993_04 |
| ORD ID | ord-c13875652fd042b99e09cb22bf04964e |
| 出典メモ | uspto-grants-1993_04 |