HCID 19768447、化合物 → HCID 19768457、化合物
反応式
[ClH:1].[O:2]=[C:3]1[NH:8][CH:7]=[C:6]([C:9]2([NH:15]C=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:4]1>CO>[ClH:1].[NH2:15][C:9]1([C:6]2[CH:5]=[CH:4][C:3](=[O:2])[NH:8][CH:7]=2)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1参加物
3
実験手順
A solution of N-[1-(1,6-dihydro-6-oxo-3-pyridinyl)cyclohexyl]formamide hydrochloride (43.0 g) in 700 ml of methanol was heated at reflux for 17 hours, and then cooled and concentrated. The residual oil was triturated with methanol affording 13.1 g of a white powder. Recrystallization from methanol gave 5.5 g of crystals, m.p. 233°-234° C.
後処理
- temperatureat reflux for 17 hours
- temperaturecooled
- concentrationconcentrated
- customThe residual oil was triturated with methanol affording 13.1 g of a white powder
- customRecrystallization from methanol
出典と根拠
- ORDレコード
- ord-4299ad7eda494d09b4bc233c25116a2e
- 出典データセット
- uspto-grants-1993_04
- 特許番号
- US05204480
反応ノート
読み込み中…