Sodium Chloride → Di-[1-(1-Methylcyclohexyloxy)-2,2,6,6-tetramethylpiperidin-4-yl] Sebacate

HRID 1590943

反応式

HRID 1590943 の反応式
[C:1]([O:5]O)([CH3:4])([CH3:3])[CH3:2].[Cl-].[Na+].[C:9]([O:32][CH:33]1[CH2:38][C:37]([CH3:40])([CH3:39])[NH:36][C:35]([CH3:42])([CH3:41])[CH2:34]1)(=[O:31])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH:21]1[CH2:26][C:25]([CH3:28])([CH3:27])[NH:24][C:23]([CH3:30])([CH3:29])[CH2:22]1)=[O:19]>[Mo](=O)(=O)=O.CC1CCCCC1>[C:9]([O:32][CH:33]1[CH2:38][C:37]([CH3:40])([CH3:39])[N:36]([O:5][C:1]2([CH3:4])[CH2:3][CH2:14][CH2:13][CH2:12][CH2:2]2)[C:35]([CH3:42])([CH3:41])[CH2:34]1)(=[O:31])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH:21]1[CH2:26][C:25]([CH3:27])([CH3:28])[N:24]([O:5][C:1]2([CH3:4])[CH2:3][CH2:11][CH2:10][CH2:9][CH2:2]2)[C:23]([CH3:29])([CH3:30])[CH2:22]1)=[O:19]

参加物

6

反応物 3

HCID 5234Sodium ChlorideHCID 6410tert-Butyl hydroperoxideHCID 164282Tinuvin 770

生成物 1

HCID 19768333Di-[1-(1-Methylcyclohexyloxy)-2,2,6,6-tetramethylpiperidin-4-yl] Sebacate収率 140.7%

試薬・触媒・溶媒 2

HCID 14802Molybdenum trioxide触媒HCID 7962Methylcyclohexane溶媒2 回

実験手順

t-Butyl hydroperoxide (70%, 133.9 g, 1.04 mol), methylcyclohexane (250 ml), and sodium chloride (20 g) are agitated in a separatory funnel. The organic layer is dried over magnesium sulfate. The t-butyl hydroperoxidemethylcyclohexane solution is mixed with 50.0 g (104 mmol) of di-(2,2,6,6-tetramethylpiperidin-4-yl) sebacate, 3.0 g of molybdenum trioxide, and 100 ml of methylcyclohexane. The reaction mixture is heated at reflux for 4.5 hours and water is collected in a Dean-Stark trap. The reaction is cooled to room temperature and filtered. The filtrate is concentrated at reduced pressure to obtain an oil which is purified by flash chromatography (silica gel; 19:1 heptane:ethyl acetate) to obtain 51.6 g (72% yield) of a colorless oil.

後処理

  1. dry with materialThe organic layer is dried over magnesium sulfate
  2. temperatureThe reaction mixture is heated
  3. temperatureat reflux for 4.5 hours
  4. customwater is collected in a Dean-Stark trap
  5. filtrationfiltered
  6. concentrationThe filtrate is concentrated at reduced pressure
  7. customto obtain an oil which
  8. customis purified by flash chromatography (silica gel; 19:1 heptane:ethyl acetate)

出典と根拠

ORDレコード
ord-11708737ad92458586bfb04c20f93784
出典データセット
uspto-grants-1993_04
特許番号
US05204473

関連ノート

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