4-Acetamido-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine → 4-Amino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine

HRID 1590947ノート

反応式

HRID 1590947 の反応式
C([NH:4][CH:5]1[CH2:10][C:9]([CH3:12])([CH3:11])[N:8]([O:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:7]([CH3:21])([CH3:20])[CH2:6]1)(=O)C>O.Cl>[NH2:4][CH:5]1[CH2:10][C:9]([CH3:11])([CH3:12])[N:8]([O:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:7]([CH3:21])([CH3:20])[CH2:6]1

参加物

4

反応物 1

HCID 233721204-Acetamido-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine

生成物 1

HCID 222779844-Amino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒

実験手順

A solution of 5.0 g of the acetamide from Example 47 in 7.5 ml of water and 7.5 ml of conc. hydrochloric acid is heated at reflux for 10 hours. The reaction mixture is then quenched with saturated sodium carbonate and extracted with ethyl acetate. The combined organic extracts are washed with water, brine, dried (MgSO4) and evaporated to leave a light brown oil. Distillation (Kugelrohr, 140° C. @ 1.5 mm) affords the title compound as a clear colorless oil.

後処理

  1. temperatureat reflux for 10 hours
  2. customThe reaction mixture is then quenched with saturated sodium carbonate
  3. extractionextracted with ethyl acetate
  4. washThe combined organic extracts are washed with water, brine
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customto leave a light brown oil
  8. distillationDistillation (Kugelrohr, 140° C. @ 1.5 mm)

出典と根拠

ORDレコード
ord-20400bae19bc435083a1307f1c5118eb
出典データセット
uspto-grants-1993_04
特許番号
US05204473

反応ノート

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