Hydrochloric Acid → 2-(2,6-Dichloro-4-trifluoromethylphenyl)-imidazole-4,5-dicarboxamide

HRID 1591089ノート

反応式

HRID 1591089 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4](Cl)[C:3]=1[C:13]1[NH:14][C:15]([C:20]#[N:21])=[C:16]([C:18]#[N:19])[N:17]=1.[OH-:22].[K+].[ClH:24].C([OH:27])C>O>[Cl:24][C:4]1[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=[C:2]([Cl:1])[C:3]=1[C:13]1[NH:14][C:15]([C:20]([NH2:21])=[O:27])=[C:16]([C:18]([NH2:19])=[O:22])[N:17]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 189476852-(2,6-Dichloro-4-trifluoromethylphenyl)-4,5-dicyanoimidazole

生成物 1

HCID 189476912-(2,6-Dichloro-4-trifluoromethylphenyl)-imidazole-4,5-dicarboxamide

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of 2-(2,6-dichloro-4-trifluoromethylphenyl)-4,5-dicyanoimidazole (3.3 g, 0.01 mol) and potassium hydroxide (85%, 1.64 g, 0.025 mol) in ethanol (20 ml) and water (2 ml) was heated at reflux for 3.5 hours. After cooling the mixture was poured into water (100 ml) and acidified to pH1 by the addition of concentrated hydrochloric acid. The precipitated solid was filtered off and dried at 80° C. and 10 mm Hg to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-imidazole-4,5-dicarboxamide (0.6 g), m.p. 306°-308° C., as an off white solid.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. temperatureAfter cooling the mixture
  4. filtrationThe precipitated solid was filtered off
  5. customdried at 80° C.

出典と根拠

ORDレコード
ord-193ee0310a2740ecaa8efac82a5b674f
出典データセット
uspto-grants-1993_04
特許番号
US05206257

反応ノート

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