化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → 2-Cyano-5-(dimethylamino)-N,N-dimethylpenta-2,4-dienamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3-(Dimethylamino)-2-propenal | HCID 79125 | — |
| 反応物 | 2-Cyano-N,N-dimethylacetamide | HCID 251143 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Cyano-5-(dimethylamino)-N,N-dimethylpenta-2,4-dienamide | HCID 54570707 | 70.4% |
反応手順
3-Dimethylaminoacrolein (25 g, 0.25 mol) and cyanoacetic acid N,N-dimethylamide (28 g, 0.25 mol) were dissolved in toluene (250 ml) and piperidine (1 ml) and acetic acid (2.5 ml) were then added. The solution was heated under reflux in a water separator until no more water was formed (about 2 hours). The solution was then filtered and reduced to about 100 ml. On cooling, crystals formed which were filtered off under suction and dried to give 34 g 1-cyano-1- dimethylaminocarbonyl-4-dimethylamino-1,3-butadiene as yellow-brown crystals, m.pt. 149°-150° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05206372 |
| 出典データセット | uspto-grants-1993_04 |
| ORD ID | ord-2d74e6310d284c6db3fc4c34764ee7ea |
| 出典メモ | uspto-grants-1993_04 |