Formic Acid → 1-Pentanol

HRID 1591284ノート

反応式

HRID 1591284 の反応式
[CH:1](O)=[O:2].C(O[C:8](=[O:10])[CH3:9])(=O)C.[NH2:11][C:12]1[S:13][CH:14]=[C:15]([O:19][CH2:20][CH3:21])[C:16]=1[C:17]#[N:18]>O>[CH:1]([NH:11][C:12]1[S:13][CH:14]=[C:15]([O:19][CH2:20][CH3:21])[C:16]=1[C:17]#[N:18])=[O:2].[CH2:8]([OH:10])[CH2:9][CH2:14][CH2:15][CH3:16]

参加物

6

反応物 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 137423802-Amino-4-ethoxythiophene-3-carbonitrile

生成物 2

HCID 62761-PentanolHCID 13742382HCID 13742382、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

200 parts of formic acid are added dropwise to 500 parts of acetic anhydride at room temperature, and 168 parts of 2-amino-3-cyano-4-ethoxythiophene are introduced after 2 hours. The mixture is stirred for 4 hours at 50° C., after which 1000 parts of water are run into the hot mixture. The mixture is cooled and the product is then filtered off under suction, washed with water and dried. 174 parts of 2-formylamino-3-cyano-4-ethoxythiophene of melting point 191°-192° C. (from pentanol) are obtained.

後処理

  1. temperatureThe mixture is cooled
  2. filtrationthe product is then filtered off under suction
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-8a91f6767cb24a1ebf79699d8a5ea29b
出典データセット
uspto-grants-1993_04
特許番号
US05206375

反応ノート

読み込み中…