Formic Acid → 2-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile

HRID 1591289ノート

反応式

HRID 1591289 の反応式
CN(C)C=[N:4][C:5]1[S:6][C:7]([CH:13]=[O:14])=[C:8]([Cl:12])[C:9]=1[C:10]#[N:11].C(O)=O>O>[NH2:4][C:5]1[S:6][C:7]([CH:13]=[O:14])=[C:8]([Cl:12])[C:9]=1[C:10]#[N:11]

参加物

4

反応物 2

HCID 284Formic AcidHCID 54382946N'-(4-chloro-3-cyano-5-formyl-2-thienyl)-N,N-dimethylformamidine

生成物 1

HCID 27376122-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile収率 90%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

48.3 parts of N,N-dimethyl-N'-(4-chloro-3-cyano-5-formylthien-2-yl)-formamidine in a mixture of 200 parts of formic acid and 200 parts of water are heated at the boil for 3 hours. After the mixture has cooled to room temperature, the product is filtered off under suction, washed with water and dried. 33.5 parts (90% of theory) of 2-amino-4-chloro-3-cyano-5-formylthiophene are obtained. Decomposition temperature: 270° C. (from glacial acetic acid), IR (KBr): 3377, 3298, 3156 (NH2), 2216 (C≡N), 1623 cm-1 (C=0).

後処理

  1. temperatureare heated at the boil for 3 hours
  2. filtrationthe product is filtered off under suction
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-f6503d4ad621412186de212853a8b31d
出典データセット
uspto-grants-1993_04
特許番号
US05206375

反応ノート

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