Thiophenol → 2-Amino-3-cyano-5-formyl-4-phenylthiothiophene

HRID 1591298ノート

反応式

HRID 1591298 の反応式
[NH2:1][C:2]1[S:3][C:4]([CH:10]=[O:11])=[C:5](Cl)[C:6]=1[C:7]#[N:8].[C:12]1([SH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C[O-].[Na+]>CO>[NH2:1][C:2]1[S:3][C:4]([CH:10]=[O:11])=[C:5]([S:18][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]=1[C:7]#[N:8]

参加物

5

反応物 3

HCID 7969ThiophenolHCID 27376122-Amino-4-chloro-5-formyl-3-thiophenecarbonitrileHCID 10942334Sodium Methoxide

生成物 1

HCID 197667672-Amino-3-cyano-5-formyl-4-phenylthiothiophene収率 81%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

18.7 parts of 2-amino-4-chloro-3-cyano-5-formylthiophene are added to a solution of 11 parts of thiophenol, 5.4 parts of a 30% strength methanolic sodium methylate solution and 100 parts of methanol. The mixture is heated at the boil for 0.5 hour, after which it is allowed to cool and the precipitated product is filtered off under suction, washed with methanol, and then with water and dried. 21 parts (81% of theory) of 2-amino-3-cyano-5-formyl-4-phenylthiothiophene are obtained.

後処理

  1. temperatureThe mixture is heated at the boil for 0.5 hour
  2. temperatureto cool
  3. filtrationthe precipitated product is filtered off under suction
  4. washwashed with methanol
  5. dry with materialwith water and dried

出典と根拠

ORDレコード
ord-70ddab2daf19419bbaa22ed55c413ed2
出典データセット
uspto-grants-1993_04
特許番号
US05206375

反応ノート

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