Benzenesulfinic acid, sodium salt → 2-Amino-3-cyano-5-formyl-4-phenylsulfonylthiophene

HRID 1591301ノート

反応式

HRID 1591301 の反応式
[C:1]1([S:7]([O-:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[NH2:11][C:12]1[S:13][C:14]([CH:20]=[O:21])=[C:15](Cl)[C:16]=1[C:17]#[N:18]>O>[NH2:11][C:12]1[S:13][C:14]([CH:20]=[O:21])=[C:15]([S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])[C:16]=1[C:17]#[N:18]

参加物

4

反応物 2

HCID 2723840Benzenesulfinic acid, sodium saltHCID 27376122-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile

生成物 1

HCID 138792242-Amino-3-cyano-5-formyl-4-phenylsulfonylthiophene収率 83%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 82 parts of sodium phenylsulfinate in 500 parts of water is added to a mixture of 93.3 g of 2-amino-4-chloro-3-cyano-5-formylthiophene an 500 parts of methylglycol, and the reaction mixture is heated at the boil for 6 hours. Thereafter, the solution is filtered while hot and the filtrate is left to stand overnight. The precipitated product is then filtered off under suction, washed with water and dried. 121 parts (83% of theory) of 2-amino-3-cyano-5-formyl-4-phenylsulfonylthiophene are obtained.

後処理

  1. temperaturethe reaction mixture is heated at the boil for 6 hours
  2. filtrationThereafter, the solution is filtered while hot and the filtrate
  3. waitis left
  4. filtrationThe precipitated product is then filtered off under suction
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-c097305c49444c68816d24638c9acec1
出典データセット
uspto-grants-1993_04
特許番号
US05206375

反応ノート

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