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HRID 1591466作成日：2026年10月27日

(S)-3-Amino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one → 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(S)-yl]-butanamide

https://huagongshe.com/reaction/1591466

反応式

関与物質

役割名称HCID仕込み量
反応物(S)-3-Amino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-oneHCID 10241317—
反応物3-(((Benzyloxy)carbonyl)amino)-3-methylbutanoic acidHCID 14551007—
生成物3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(S)-yl]-butanamideHCID 18651462—

反応手順

Prepared from 3(S)-amino-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (Example 1, Step B) and 3-benzyloxycarbonylamino-3-methylbutanoic acid (Example 1, Step E) by the procedure described in Example 1, Step F. FAB-MS: calculated for C23H27N3O4 409; found 410 (M+H,100%). [a]D =- 160° (c=1,CHCl3).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05206235
出典データセットuspto-grants-1993_04
ORD IDord-a83d346f1224478788849bb68f8a6592
出典メモuspto-grants-1993_04