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Pyridine-2-carboximidamide hydrochloride → HCID 178515631、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine-2-carboximidamide hydrochloride | HCID 12403615 | — |
| 反応物 | 4-Chloropyridine-2-carboximidamide hydrochloride | HCID 21882000 | — |
| 反応物 | 6-(4-chloro-2-pyridinyl)-2-pyridin-2-yl-1H-pyrimidin-4-one | HCID 178515630 | — |
| 生成物 | HCID 178515631 | HCID 178515631 | — |
反応手順
The procedure is as described in the case of 6-(4-chloropyrid-2-yl)-2-pyrid-2-yl-pyrimidin-4-ol (ligand PM1) in Example 3 except that, instead of 2-amidinopyridine hydrochloride, the 2-amidino4-chloropyridine hydrochloride from Example 8 is used. After recrystallisation from DMSO, 2,6-bis(4-chloropyrid-2-yl)-pyrimidin-4-ol (ligand PM5) is obtained in the form of a colourless solid. 1H-NMR (360 MHz, DMSO-d6): 12.53 (br s, 1H); 8.74 (d, J=5.0 Hz, 1H); 8.74 (s, 1H); 8.71 (d, J=5.0 Hz, 1H); 8.64 (d, J=2.3 Hz, 1H); 7.83 (dd, J=5.0, 2.3 Hz, 1H); 7.71 (dd, J=5.0, 2.3 Hz, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07291584B2 |
| 出典データセット | uspto-grants-2007_11 |
| ORD ID | ord-61ef33f0b3c14684a9b530fedefc6bea |
| 出典メモ | uspto-grants-2007_11 |