ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Ethylenediamine → N-{3-[(2,3-Dichlorobenzenesulphonyl)methylamino]-propyl}-3-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]propionamide

HRID 1591749
ノート
印刷プレビュー

反応式

HRID 1591749 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([NH:13][CH2:14][CH2:15][CH2:16][NH:17][CH2:18][S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:23]=2[Cl:29])(=[O:21])=[O:20])=[O:12])=[CH:5][CH:4]=1)#[N:2].[CH2:30](N)[CH2:31][NH2:32].[S]>O>[Cl:29][C:23]1[C:24]([Cl:28])=[CH:25][CH:26]=[CH:27][C:22]=1[S:19]([CH2:18][NH:17][CH2:16][CH2:15][CH2:14][NH:13][C:11](=[O:12])[CH2:10][CH2:9][C:6]1[CH:5]=[CH:4][C:3]([C:1]2[NH:32][CH2:31][CH2:30][N:2]=2)=[CH:8][CH:7]=1)(=[O:21])=[O:20]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 3301EthylenediamineHCID 5362487SulfurHCID 694217413-(4-Cyanophenyl)-N-{3-[(2,3-dichlorobenzenesulphonyl)methyl-amino]propyl}propionamide

生成物 1

HCID 69423023N-{3-[(2,3-Dichlorobenzenesulphonyl)methylamino]-propyl}-3-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]propionamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 0.7 g (1.54 mmol) of 3-(4-cyanophenyl)-N-{3-[(2,3-dichloro-benzenesulphonyl)methylamino]propyl}propionamide, 3 ml of ethylenediamine and 0.10 g (3.12 mmol) of sulphur was stirred at 100° C. for 15 minutes. Water was then added, and the mixture was extracted with ethyl acetate. The organic extracts were washed with water and saturated sodium chloride solution, dried over sodium sulphate and concentrated. The crude product obtained in this manner was purified by column chromatography on alumina (mobile phase: dichloromethane/methanol 100:1) and then crystallized from ethyl acetate/diethyl ether.

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic extracts were washed with water and saturated sodium chloride solution
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-54b15a7d84a3498ea76b22af7d8dc7a9
出典データセット
uspto-grants-2007_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07291642B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート