Acetic Acid → 2,6-Diisopropylphenyl acetate

HRID 1591785

反応式

HRID 1591785 の反応式
FC(F)(F)C(OC(=O)C(F)(F)F)=O.[C:14]([OH:17])(=[O:16])[CH3:15].[CH:18]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]([CH3:29])[CH3:28])[C:22]=1O)([CH3:20])[CH3:19]>O>[C:14]([O:17][C:22]1[C:21]([CH:18]([CH3:19])[CH3:20])=[CH:26][CH:25]=[CH:24][C:23]=1[CH:27]([CH3:29])[CH3:28])(=[O:16])[CH3:15]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 4943PropofolHCID 9845Trifluoroacetic anhydride

生成物 1

HCID 5960912,6-Diisopropylphenyl acetate収率 86%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

3.45 g (16.4 mmol) of trifluoroacetic anhydride is added to 0.83 ml (14.6 mmol) of acetic acid at 0° C. while leaving the mixture to return to ambient temperature over 2 hours. The mixture is then cooled down to 0° C. and 1.95 g (11.0 mmol) of 2,6-diisopropylphenol is added dropwise. The reaction medium is maintained under stirring for 12 hours before being poured into ice-cooled water. After extraction with dichloromethane, the organic phase is washed with sodium chloride in a saturated aqueous solution before being dried over magnesium sulphate, filtered and concentrated under vacuum. A colourless oil is obtained with a yield of 86%. This product is sufficiently pure to be used directly in the following stage.

後処理

  1. customwhile leaving the mixture
  2. temperatureThe reaction medium is maintained
  3. additionbefore being poured into ice-
  4. extractionAfter extraction with dichloromethane
  5. washthe organic phase is washed with sodium chloride in a saturated aqueous solution
  6. dry with materialbefore being dried over magnesium sulphate
  7. filtrationfiltered
  8. concentrationconcentrated under vacuum
  9. customA colourless oil is obtained with a yield of 86%

出典と根拠

ORDレコード
ord-089bc96436fc4235a487ca9598681b01
出典データセット
uspto-grants-2007_11
特許番号
US07291641B2

関連ノート

読み込み中…