(5-Fluoropyridin-3-yl)boronic acid → 4-Fluoro-1-(2-fluoro-5-(5-fluoropyridin-3-yl)phenyl)-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine

反応式

[Br:1][c:2]1[cH:3][cH:4][c:5]([F:26])[c:6]([C:8]2([c:19]3[cH:20][c:21]([CH3:25])[n:22][cH:23][cH:24]3)[N:9]=[C:10]([NH2:18])[c:11]3[c:12]([F:17])[cH:13][cH:14][cH:15][c:16]32)[cH:7]1.[F:27][c:28]1[cH:29][c:30]([B:34]([OH:35])[OH:36])[cH:31][n:32][cH:33]1>>[c:2]1(-[c:30]2[cH:29][c:28]([F:27])[cH:33][n:32][cH:31]2)[cH:3][cH:4][c:5]([F:26])[c:6]([C:8]2([c:19]3[cH:20][c:21]([CH3:25])[n:22][cH:23][cH:24]3)[N:9]=[C:10]([NH2:18])[c:11]3[c:12]([F:17])[cH:13][cH:14][cH:15][c:16]32)[cH:7]1

参加物

反応物 2

HCID 44717403(5-Fluoropyridin-3-yl)boronic acid

HCID 585794991-(5-Bromo-2-fluorophenyl)-4-fluoro-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine

生成物 1

HCID 462056404-Fluoro-1-(2-fluoro-5-(5-fluoropyridin-3-yl)phenyl)-1-(2-methylpyridin-4-yl)-1H-isoindol-3-amine

出典と根拠

ORDレコード: ord-6a659eb2f1794930a6a835e42ee4a8ed
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…