N-Ethyl-3-nitro PABA → 3-Amino-4-(ethylamino)benzoic acid
反応式
[CH2:1]([NH:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]=1[N+:13]([O-])=O)[CH3:2]>C1COCC1.O.[Ni]>[NH2:13][C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:4]=1[NH:3][CH2:1][CH3:2])[C:8]([OH:10])=[O:9]参加物
4
実験手順
A solution of 1.56 g (7.4 mmol) of the title A compound 4-ethylamino-3-nitro-benzoic acid in 60 mL of THF/water (2:1) is hydrogenated at 20 psi over 300 mg of Raney nickel for 18 h. The catalyst is removed by filtration through Celite and the solvent is removed under reduced pressure to give 3-amino-4-ethylamino-benzoic acid as a dark solid. This material is used as such in the next step.
後処理
- customThe catalyst is removed by filtration through Celite
- customthe solvent is removed under reduced pressure
出典と根拠
- ORDレコード
- ord-6d237297cbed410e884e3be43b602fb6
- 出典データセット
- uspto-grants-2007_11
- 特許番号
- US07291635B2
反応ノート
読み込み中…