Potassium Carbonate → 4-(2,6-Difluorobenzyloxy)-6-(2-butynyloxy)pyrimidine

関与物質

反応条件

反応手順

To 2 ml of N,N-dimethylformamide were added 0.15 g of 4-(2-butynyloxy)-6-methanesulfonylpyrimidine, 0.14 g of potassium carbonate, and 0.16 g of 2,6-difluorobenzylalcohol, followed by stirring at 50° C. for 7 hours. The reaction mixture was then left for cooling to room temperature and poured into a saturated aqueous ammonium chloride solution, which was extracted three times with chloroform. The chloroform layers were combined, washed with diluted hydrochloric acid and then with water, and dried over anhydrous magnesium sulfate and then concentrated. The residue was subjected to silica gel column chromatography to give 0.14 g of 4-(2,6-difluorobenzyloxy)-6-(2-butynyloxy)pyrimidine (the present compound (68)).

情報源と証拠