Aluminium lithium hydride → 3-(4-Fluorophenyl)propanal

HRID 1592350ノート

反応式

HRID 1592350 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](N(OC)C)=[O:11])=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>CCOCC>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH:10]=[O:11])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 22612404N-Methoxy-N-methyl-4-fluoro-benzenepropanamide

生成物 1

HCID 101977823-(4-Fluorophenyl)propanal

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

The crude amide was dissolved in ether and cooled in an ice bath and treated with LAH (1.35 g, 35 mmol) and stirred for 1 hour. The reaction was quenched with 1 N HCl, extracted with ethyl acetate and washed successively with water and brine, dried over MgSO4. The extract was filtered and evaporated under vacuum to give 4.3 g of 3-(4-fluorophenyl)propanal.

後処理

  1. temperaturecooled in an ice bath
  2. customThe reaction was quenched with 1 N HCl
  3. extractionextracted with ethyl acetate
  4. washwashed successively with water and brine
  5. dry with materialdried over MgSO4
  6. filtrationThe extract was filtered
  7. customevaporated under vacuum

出典と根拠

ORDレコード
ord-8fc62ebd43a44bc299c210eec26b1a11
出典データセット
uspto-grants-2007_11
特許番号
US07291744B2

反応ノート

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