N-(4-Aminobutyl)-N-methyl carbamic acid tert-butyl ester → {4-[(5-Chloro-3-methyl-pyridin-2-ylmethyl)-amino]-butyl}-methyl-carbamic acid tert-butyl ester

HRID 1592376

反応式

HRID 1592376 の反応式
[C:1]([O:5][C:6](=[O:14])[N:7]([CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])[CH3:8])([CH3:4])([CH3:3])[CH3:2].[Cl:15][C:16]1[CH:17]=[C:18]([CH3:24])[C:19]([CH:22]=O)=[N:20][CH:21]=1>>[C:1]([O:5][C:6](=[O:14])[N:7]([CH2:9][CH2:10][CH2:11][CH2:12][NH:13][CH2:22][C:19]1[C:18]([CH3:24])=[CH:17][C:16]([Cl:15])=[CH:21][N:20]=1)[CH3:8])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 2756377N-(4-Aminobutyl)-N-methyl carbamic acid tert-butyl esterHCID 722140555-Chloro-3-methylpicolinaldehyde

生成物 1

HCID 58996945{4-[(5-Chloro-3-methyl-pyridin-2-ylmethyl)-amino]-butyl}-methyl-carbamic acid tert-butyl ester

実験手順

Yellow oil prepared from (4-amino-butyl)-methyl-carbamic acid tert-butyl ester and 5-chloro-3-methyl-pyridine-2-carbaldehyde. 1H NMR (CDCl3) δ 1.44 (s, 9H), 1.50-1.60 (m, 4H), 2.27(s, 3H), 2.30-2.36 (m, 2H), 2.83 (s, 3H), 3.20-3.26 (m, 2H), 3.83 (s, 2H), 8.34 (d, 1H, J=1.5 Hz), 7.4 (d, 1H, J=1.9 Hz).

出典と根拠

ORDレコード
ord-d9f7134e6b08490fb92ae823ae5d5a69
出典データセット
uspto-grants-2007_11
特許番号
US07291631B2

関連ノート

読み込み中…