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2-(4-Oxopentyl)-1H-isoindole-1,3(2H)-dione → 2-[4-(1-Pyridin-2-yl-ethylamino)-pentyl]-isoindole-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(4-Oxopentyl)-1H-isoindole-1,3(2H)-dione | HCID 236270 | — |
| 反応物 | 1-(Pyridin-2-yl)ethan-1-amine | HCID 541877 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-[4-(1-Pyridin-2-yl-ethylamino)-pentyl]-isoindole-1,3-dione | HCID 67272300 | — |
反応手順
Using General Procedure B: Reaction of 2-(4-oxo-pentyl)-isoindole-1,3-dione (Abdel-Monem, MM et al. J. Med. Chem. 1974, 17, 447-451) in CH2Cl2 and 1-pyridin-2-yl-ethylamine with NaBH(OAc)3 gave 2-[4-(1-pyridin-2-yl-ethylamino)-pentyl]-isoindole-1,3-dione as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07291631B2 |
| 出典データセット | uspto-grants-2007_11 |
| ORD ID | ord-fbef4395ff2a4655b45a69b2aaa24091 |
| 出典メモ | uspto-grants-2007_11 |