3-(Dimethylamino)-1-(4-fluorophenyl)-2-(pyridin-4-yl)prop-2-en-1-one → HCID 178505663、化合物

反応式

C[N:2](C)[CH:3]=[C:4]([C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1)[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=1)=O.C[N:22](C)C=C(C1C=CN=CC=1)C(C1C=CC(F)=CC=1)=O>>[F:13][C:9]1[CH:8]=[C:7]([C:5]2[C:4]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)=[CH:3][NH:2][N:22]=2)[CH:12]=[CH:11][CH:10]=1

参加物

反応物 2

HCID 545188383-(Dimethylamino)-1-(4-fluorophenyl)-2-(pyridin-4-yl)prop-2-en-1-one

HCID 694147713-Dimethylamino-1-(3-fluorophenyl)-2-(pyridin-4-yl)-2-propen-1-one

生成物 1

HCID 178505663HCID 178505663、化合物収率 70%

実験手順

The reaction was carried out in the same manner as in Example 1-2) except for using 18.3 g (67.7 mmol) of 3-dimethylamino-1-(3-fluorophenyl)-2-(pyridin-4-yl)-2-propen-1-one obtained in Example 7-1) in place of 3-dimethylamino-1-(4-fluorophenyl)-2-(pyridin-4-yl)-2-propen-1-one to obtain 11.3 g of the title compound as a white powder. (Yield: 70%)

出典と根拠

ORDレコード: ord-eae09fec9eab4024ad8d439c241bd009
出典データセット: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07294625B2

反応ノート

読み込み中…

参加物