2-(2-t-Butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(3-fluorophenyl)-2-propen-1-one → HCID 178452640、化合物

HRID 1592891ノート

反応式

HRID 1592891 の反応式
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([C:15](=[CH:25][N:26](C)C)[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=2)=O)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC([NH:36]C1C=C(C(=CN(C)C)C(C2C=CC(F)=CC=2)=O)C=CN=1)=O)(C)(C)C>>[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([C:15]2[C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=3)=[N:36][NH:26][CH:25]=2)[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 694151992-(2-t-Butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(3-fluorophenyl)-2-propen-1-oneHCID 694159932-(2-t-Butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(4-fluorophenyl)-2-propen-1-one

生成物 1

HCID 178452640HCID 178452640、化合物

実験手順

The reaction was carried out in the same manner as in Example 2-2) except for using 13.5 g (35.0 mmol) of 2-(2-t-butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(3-fluorophenyl)-2-propen-1-one obtained in Example 22-1) in place of 2-(2-t-butoxycarbonylaminopyridin-4-yl)-3-dimethylamino-1-(4-fluorophenyl)-2-propen-1-one to obtain 12.4 g of the title compound as a yellowish white powder. (Yield: quantitative)

出典と根拠

ORDレコード
ord-904fd1bec4a1465bb6874fa7c45663ee
出典データセット
uspto-grants-2007_11
特許番号
US07294625B2

反応ノート

読み込み中…