1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid → 4-(3-Benzyl-[1,2,4]oxadiazol-5-yl)-piperidine hydrochloride

HRID 1593002

反応式

HRID 1593002 の反応式
ON=C(N)CC1C=CC=CC=1.C(OC(N1CCC(C(O)=O)CC1)=O)(C)(C)C.[ClH:28].CS[C:31]1[CH:48]=[CH:47][C:34]([CH2:35][C:36]2[N:40]=[C:39]([CH:41]3[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]3)[O:38][N:37]=2)=[CH:33][CH:32]=1>>[ClH:28].[CH2:35]([C:36]1[N:40]=[C:39]([CH:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)[O:38][N:37]=1)[C:34]1[CH:33]=[CH:32][CH:31]=[CH:48][CH:47]=1

参加物

4

反応物 3

HCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acidHCID 2731007N'-hydroxy-2-phenylethanimidamideHCID 687091324-{3-[4-(Methylthio)benzyl]-1,2,4-oxadiazol-5-yl}piperidine hydrochloride

生成物 1

HCID 687073304-(3-Benzyl-[1,2,4]oxadiazol-5-yl)-piperidine hydrochloride

実験手順

This was prepared from N′-hydroxy-2-phenylethanimidamide and 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid using a similar method to that used to prepare 4-{3-[4-(methylthio)benzyl]-1,2,4-oxadiazol-5-yl}piperidine hydrochloride (Method E, Steps 1, 2); NMR: 1.96 (2H, m), 2.15(2H, dd), 3.01(2H, t), 3.24 (2H, dd), 3.40 (1H, m), 4.09 (2H, s), 7.25 (5H, m), 9.31(2H, br s); MS: 244 (MH+).

出典と根拠

ORDレコード
ord-f2899366c5f24882966ea61fb6ed9126
出典データセット
uspto-grants-2007_11
特許番号
US07294636B2

関連ノート

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