Hydrochloric Acid → HCID 45094991、化合物

HRID 1593022ノート

反応式

HRID 1593022 の反応式
[CH2:1]([CH:3]1[C:7](=[O:8])[N:6]([CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[C:5](=[O:22])[NH:4]1)[CH3:2].Cl.C(OCC)C>O1CCOCC1>[CH2:1]([CH:3]1[NH:4][C:5](=[O:22])[N:6]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:7]1=[O:8])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 69448964HCID 69448964、化合物

生成物 1

HCID 45094991HCID 45094991、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a suspension of tert-butyl 4-(4-ethyl-2,5-dioxoimidazolidin-1-yl)piperidine-1-carboxylate (1.12 g) in dioxane (10 ml) was added a solution of 4M HCl in dioxane (10 ml) and the resulting mixture was stirred for 1 hour. Diethyl ether (20 ml) was added and the mixture was filtered and washed with diethyl ether to give 5-ethyl-3-piperidin-4-ylimidazolidine-2,4-dione. Yield 687 mg. MS 212 MH+

後処理

  1. filtrationthe mixture was filtered
  2. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-eb36e12cfd174a43ad4c119609322543
出典データセット
uspto-grants-2007_11
特許番号
US07294636B2

反応ノート

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