Acetyl chloride → Acetic acid, (2-fluoro-5-nitrophenyl)methyl ester

HRID 1593061ノート

反応式

HRID 1593061 の反応式
[F:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH2:4][OH:5].C(N(CC)CC)C.[C:20](Cl)(=[O:22])[CH3:21]>ClCCl.C(OCC)(=O)C>[F:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH2:4][O:5][C:20](=[O:22])[CH3:21]

参加物

6

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 4437169(2-Fluoro-5-nitrophenyl)methanol

生成物 1

HCID 58998466Acetic acid, (2-fluoro-5-nitrophenyl)methyl ester

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2-fluoro-5-nitrobenzyl alcohol (1 g, 5.84 mmol) in 5 mL dichloromethane and triethylamine (0.81 ml, 5.84 mmol), was added acetyl chloride (0.415 ml, 1 eq) dropwise. The solution was stirred at room temperature for 12 hours, diluted with ethyl acetate and extracted with brine. Combine organic layers was dried over sodium sulfate, concentrated in vacuo to give acetic acid 2-fluoro-5-nitro-benzyl ester.

後処理

  1. extractionextracted with brine
  2. dry with materialCombine organic layers was dried over sodium sulfate
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-3073f91f13654132910e07b6f1ce6d29
出典データセット
uspto-grants-2007_11
特許番号
US07294635B2

反応ノート

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