2-Isopropylaniline → 4-Iodo-2-(propan-2-yl)aniline
反応式
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH2:10])([CH3:3])[CH3:2].C([O-])(=O)C.[Na+].[Cl-].[I-:17]>C(O)(=O)C.C(OCC)(=O)C>[I:17][C:8]1[CH:7]=[CH:6][C:5]([NH2:10])=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:9]=1参加物
6
実験手順
To a solution of 2-isopropyl-phenylamine (262 mg, 1.94 mmol) and sodium acetate (159 mg, 1.94 mmol) in 5 mL acetic acid, was added iodide monochloride (409 mg, 2.58 mmol) at room temperature. The mixture was stirred at room temperature for 20 minutes, then diluted with ethyl acetate and washed with saturated sodium bicarbonate. The organic layers were combined and concentrated in vacuo to give a crude residue, which was purified by column chromatography (silica 5-25% EtOAc/hexane) to give 4-iodo-2-isopropyl-phenylamine.
後処理
- washwashed with saturated sodium bicarbonate
- concentrationconcentrated in vacuo
- customto give a crude residue, which
- customwas purified by column chromatography (silica 5-25% EtOAc/hexane)
出典と根拠
- ORDレコード
- ord-418f422171b7461eaa9adc007a0f8c4b
- 出典データセット
- uspto-grants-2007_11
- 特許番号
- US07294635B2
反応ノート
読み込み中…