Hydrochloric Acid → 2-Cyclopropylquinazoline-6-carboxylic acid
反応式
C[CH:2]([OH:4])[CH3:3].[CH:5]1([C:8]2[N:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=C(C#N)[CH:14]=3)[N:9]=2)[CH2:7][CH2:6]1.[OH-:20].[K+].Cl>O>[CH:5]1([C:8]2[N:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:3]([C:2]([OH:4])=[O:20])[CH:14]=3)[N:9]=2)[CH2:7][CH2:6]1参加物
6
実験手順
Into 8 ml of 2-propanol and 1 ml of water were dissolved 210 mg of 2-cyclopropylquinazoline-6-carbonitrile and 450 mg of potassium hydroxide, followed by heating under refluxing overnight. Hydrochloric acid was added thereto and the solvent was removed by evaporation to obtain the title compound as a crude carboxylic acid.
後処理
- temperatureby heating
- temperatureunder refluxing overnight
- customthe solvent was removed by evaporation
出典と根拠
- ORDレコード
- ord-bc5bbe1747a94d5eb61ba7ee5ccd0dc9
- 出典データセット
- uspto-grants-2007_11
- 特許番号
- US07297698B2
反応ノート
読み込み中…