1-[2-(Methylsulfanyl)pyrimidin-5-yl]ethan-1-one → 5-[(E)-3-(2-Methylsulfanylpyrimidin-5-yl)-3-oxopropenyl]indan-1-one O-methyloxime

反応式

[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][N:4]=1.[CH3:12][O:13][N:14]=[C:15]1[C:23]2[C:18](=[CH:19][C:20]([CH:24]=O)=[CH:21][CH:22]=2)[CH2:17][CH2:16]1>>[CH3:12][O:13][N:14]=[C:15]1[C:23]2[C:18](=[CH:19][C:20](/[CH:24]=[CH:10]/[C:9]([C:6]3[CH:7]=[N:8][C:3]([S:2][CH3:1])=[N:4][CH:5]=3)=[O:11])=[CH:21][CH:22]=2)[CH2:17][CH2:16]1

参加物

反応物 2

HCID 127928091-[2-(Methylsulfanyl)pyrimidin-5-yl]ethan-1-one

HCID 730123441-(Methoxyimino)-2,3-dihydro-1H-indene-5-carbaldehyde

生成物 1

HCID 865954145-[(E)-3-(2-Methylsulfanylpyrimidin-5-yl)-3-oxopropenyl]indan-1-one O-methyloxime収率 28%

実験手順

The title compound (2.6 g, 28%) was prepared from the product of Step 1 and the product of Example 1 Step 2 using the method of Example 2 Step 1; MS(ES+) m/e 340 [M+H]+.

出典と根拠

ORDレコード: ord-8f135b757e6549fda0596c8a79e66839
出典データセット: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07297694B2

反応ノート

読み込み中…